Structure Modeling Using Genetically Engineered Crosslinking
نویسندگان
چکیده
Class B G-protein-coupled receptors are exciting drug targets, yet the structure of a complete receptor bound to a peptide agonist has remained elusive. Coin et al. present a model of the receptor CRF1R bound to its native ligand based on partial structures and 44 spatial constraints revealed by new crosslinking approaches.
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عنوان ژورنال:
- Cell
دوره 155 شماره
صفحات -
تاریخ انتشار 2013